:root{--primary-50:#ecfdf5;--primary-100:#d1fae5;--primary-500:#10b981;--primary-600:#059669;--primary-700:#047857;--teal-500:#0d9488;--indigo-500:#6366f1;--indigo-600:#4f46e5;--bg-app:#f8fafc;--bg-surface:#fff;--bg-surface-glass:rgba(255,255,255,.85);--bg-subtle:#f1f5f9;--border-color:#e2e8f0;--border-hover:#cbd5e1;--text-main:#0f172a;--text-muted:#475569;--text-light:#64748b;--success:#10b981;--success-bg:#f0fdf4;--warning:#f59e0b;--warning-bg:#fffbe6;--danger:#ef4444;--danger-bg:#fef2f2;--info:#3b82f6;--info-bg:#eff6ff;--shadow-sm:0 1px 2px 0 rgba(0,0,0,.05);--shadow-md:0 4px 6px -1px rgba(0,0,0,.08), 0 2px 4px -2px rgba(0,0,0,.04);--shadow-lg:0 10px 15px -3px rgba(0,0,0,.1), 0 4px 6px -4px rgba(0,0,0,.05);--shadow-glow:0 0 20px rgba(16,185,129,.25);--radius-sm:6px;--radius-md:10px;--radius-lg:16px;--radius-full:9999px;--font-sans:"Inter", -apple-system, BlinkMacSystemFont, sans-serif;--font-heading:"Plus Jakarta Sans", var(--font-sans);--font-mono:"JetBrains Mono", monospace;--transition:all .2s cubic-bezier(.4, 0, .2, 1)}[data-theme=dark]{--bg-app:#0b0f17;--bg-surface:#131b2e;--bg-surface-glass:rgba(19,27,46,.85);--bg-subtle:#212e47;--border-color:#314363;--border-hover:#465a80;--text-main:#fff;--text-muted:#d1d5db;--text-light:#a0aec0;--success-bg:rgba(16,185,129,.15);--warning-bg:rgba(245,158,11,.15);--danger-bg:rgba(239,68,68,.15);--info-bg:rgba(59,130,246,.15);--shadow-sm:0 1px 2px 0 rgba(0,0,0,.3);--shadow-md:0 4px 6px -1px rgba(0,0,0,.4);--shadow-lg:0 10px 25px -5px rgba(0,0,0,.5)}*,:before,:after{box-sizing:border-box}html,body{background-color:var(--bg-app);color:var(--text-main);font-family:var(--font-sans);-webkit-font-smoothing:antialiased;min-height:100vh;margin:0;padding:0;font-size:15px;line-height:1.6}#root{flex-direction:column;min-height:100vh;display:flex}h1,h2,h3,h4,h5,h6{font-family:var(--font-heading);color:var(--text-main);margin:0 0 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1.25rem;font-size:.9rem;font-weight:600;display:inline-flex}.btn-primary{background-color:var(--primary-600);color:#fff;box-shadow:0 2px 4px rgba(5,150,105,.2)}.btn-primary:hover{background-color:var(--primary-700);box-shadow:var(--shadow-glow);transform:translateY(-1px)}.btn-secondary{background-color:var(--bg-subtle);color:var(--text-main);border-color:var(--border-color)}.btn-secondary:hover{background-color:var(--border-color);border-color:var(--border-hover)}.btn-outline{color:var(--primary-600);border-color:var(--primary-600);background-color:transparent}.btn-outline:hover{background-color:var(--primary-50);border-color:var(--primary-700)}.btn-danger{background-color:var(--danger);color:#fff}.btn-danger:hover{background-color:#dc2626}.btn-sm{padding:.4rem .8rem;font-size:.825rem}.btn-lg{padding:.8rem 1.75rem;font-size:1rem}.form-group{margin-bottom:1.25rem}.form-label{color:var(--text-main);margin-bottom:.4rem;font-size:.9rem;font-weight:600;display:block}.form-label .required{color:var(--danger);margin-left:.25rem}.form-label .cdash-tag{font-family:var(--font-mono);background-color:var(--bg-subtle);color:var(--primary-600);border-radius:var(--radius-sm);margin-left:.5rem;padding:.15rem .4rem;font-size:.725rem;font-weight:500}.form-control{width:100%;font-family:var(--font-sans);color:var(--text-main);background-color:var(--bg-surface);border:1px solid var(--border-color);border-radius:var(--radius-md);transition:var(--transition);padding:.65rem .85rem;font-size:.925rem}.form-control:focus{border-color:var(--primary-500);outline:none;box-shadow:0 0 0 3px rgba(5,150,105,.2)}.form-control:focus-visible{border-color:var(--primary-500);outline:none;box-shadow:0 0 0 3px rgba(5,150,105,.2)}.form-control:user-invalid{border-color:var(--danger);box-shadow:0 0 0 3px rgba(239,68,68,.2)}.form-control::-webkit-input-placeholder{color:var(--text-light)}.form-control::-moz-placeholder{color:var(--text-light)}.form-control::-ms-input-placeholder{color:var(--text-light)}.form-control::placeholder{color:var(--text-light)}.form-hint{color:var(--text-light);margin-top:.3rem;font-size:.8rem}.form-unit{color:var(--text-muted);background:var(--bg-subtle);border:1px solid var(--border-color);border-radius:0 var(--radius-md) var(--radius-md) 0;border-left:none;padding:.65rem .85rem;font-size:.85rem;font-weight:600}.input-with-unit{align-items:center;display:flex}.input-with-unit .form-control{border-top-right-radius:0;border-bottom-right-radius:0}.pill-group{flex-wrap:wrap;gap:.5rem;display:flex}.pill-option{background-color:var(--bg-subtle);color:var(--text-main);border:1px solid var(--border-color);border-radius:var(--radius-md);cursor:pointer;transition:var(--transition);-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;align-items:center;gap:.4rem;padding:.55rem 1rem;font-size:.875rem;font-weight:600;display:inline-flex}.pill-option:hover{background-color:var(--border-hover);color:var(--text-main);border-color:var(--primary-500)}.pill-option.active{background-color:var(--primary-600);color:#fff;border-color:var(--primary-700);font-weight:700;box-shadow:0 4px 12px rgba(16,185,129,.35)}.pill-option input[type=radio]{accent-color:var(--primary-600)}.pill-option input[type=checkbox]{accent-color:var(--primary-600)}.badge{border-radius:var(--radius-full);text-transform:uppercase;letter-spacing:.03em;align-items:center;gap:.3rem;padding:.25rem .6rem;font-size:.75rem;font-weight:600;display:inline-flex}.badge-success{background-color:var(--success-bg);color:var(--success);border:1px solid rgba(16,185,129,.3)}.badge-warning{color:#a78bfa;background-color:rgba(167,139,250,.12);border:1px solid rgba(167,139,250,.25)}.badge-danger{background-color:var(--danger-bg);color:var(--danger);border:1px solid rgba(239,68,68,.3)}.badge-info{color:#2dd4bf;background-color:rgba(45,212,191,.12);border:1px solid rgba(45,212,191,.25)}.badge-neutral{color:var(--text-muted);border:1px solid var(--border-color);background-color:transparent}.badge-category{color:var(--text-light);border:1px solid var(--border-color);background-color:rgba(255,255,255,.03);border-radius:4px;align-items:center;padding:.2rem .5rem;font-size:.7rem;font-weight:600;display:inline-flex}.progress-bar-container{background-color:var(--bg-subtle);border-radius:var(--radius-full);width:100%;height:8px;margin:.75rem 0;overflow:hidden}.progress-bar-fill{background:linear-gradient(90deg, var(--primary-500), var(--teal-500));border-radius:var(--radius-full);height:100%;transition:width .4s}.toast-container{z-index:1000;flex-direction:column;gap:.5rem;max-width:380px;display:flex;position:fixed;bottom:1.5rem;right:1.5rem}.toast{background:var(--bg-surface);border-left:4px solid var(--primary-500);border-radius:var(--radius-md);box-shadow:var(--shadow-lg);color:var(--text-main);align-items:center;gap:.75rem;padding:.85rem 1.15rem;animation:.3s cubic-bezier(.16,1,.3,1) slideInRight;display:flex}.toast-success{border-left-color:var(--success)}.toast-danger{border-left-color:var(--danger)}.toast-warning{border-left-color:var(--warning)}@keyframes slideInRight{0%{opacity:0;transform:translate(100%)}to{opacity:1;transform:translate(0)}}.crf-layout-grid{grid-template-columns:minmax(0,1fr) 340px;gap:1.5rem;display:grid}@media (max-width:900px){.crf-layout-grid{grid-template-columns:1fr}}@media print{@page{size:A4 portrait;margin:10mm}*{color:#000!important;box-shadow:none!important;text-shadow:none!important;-webkit-filter:none!important;filter:none!important;background:0 0!important}body{color:#000!important;background:#fff!important;width:100%!important;overflow:visible!important}.no-print,header,nav,.app-header,.toast-container{display:none!important}.app-container,main{width:100%!important;max-width:100%!important;margin:0!important;padding:0!important}div[style*="position: fixed"],div[style*=position\:fixed]{width:100%!important;max-width:100%!important;box-shadow:none!important;-webkit-backdrop-filter:none!important;backdrop-filter:none!important;background:#fff!important;margin:0!important;padding:0!important;position:static!important;overflow:visible!important}div[style*=maxHeight],div[style*=max-height]{max-height:none!important;overflow:visible!important}#clinical-fiche-print-area,.card{page-break-inside:auto;box-shadow:none!important;color:#000!important;background:#fff!important;border:1px solid #cbd5e1!important;width:100%!important;max-width:100%!important;max-height:none!important;margin:0!important;padding:1rem!important;overflow:visible!important}table{page-break-inside:auto;border-collapse:collapse!important;table-layout:fixed!important;word-break:break-word!important;width:100%!important;max-width:100%!important}tr{page-break-inside:avoid!important;page-break-after:auto!important}th,td,span,div,h1,h2,h3,h4,p,label{color:#000!important;word-wrap:break-word!important;overflow-wrap:break-word!important;white-space:normal!important;border-color:#cbd5e1!important}}.home-launchpad{flex-direction:column;justify-content:center;align-items:center;gap:4rem;min-height:calc(100vh - 180px);padding:3rem 1.5rem;display:flex}.launchpad-grid{grid-template-columns:repeat(2,1fr);gap:2rem;width:100%;max-width:900px;display:grid}@media (max-width:768px){.launchpad-grid{grid-template-columns:1fr}}.launchpad-card{background-color:var(--bg-surface-glass);-webkit-backdrop-filter:blur(16px);border:1px solid var(--border-color);text-align:center;cursor:pointer;border-radius:20px;flex-direction:column;align-items:center;padding:2.5rem 2rem;transition:all .3s cubic-bezier(.25,.8,.25,1);display:flex;box-shadow:0 4px 20px rgba(0,0,0,.05)}[data-theme=dark] .launchpad-card{background-color:rgba(30,41,59,.6);box-shadow:0 4px 20px rgba(0,0,0,.2)}.launchpad-card:hover{border-color:var(--primary-400);transform:translateY(-8px);box-shadow:0 12px 30px rgba(0,0,0,.1)}[data-theme=dark] .launchpad-card:hover{box-shadow:0 12px 30px rgba(0,0,0,.4)}.launchpad-icon-wrapper{border-radius:24px;justify-content:center;align-items:center;width:80px;height:80px;margin-bottom:1.5rem;transition:transform .3s;display:flex}.launchpad-card:hover .launchpad-icon-wrapper{transform:scale(1.1)}.launchpad-title{color:var(--text-main);letter-spacing:-.01em;margin-bottom:.75rem;font-size:1.5rem;font-weight:700}.launchpad-desc{color:var(--text-light);margin:0;font-size:.95rem;line-height:1.5}.launchpad-actions{flex-wrap:wrap;justify-content:center;gap:1.5rem;display:flex}.launchpad-btn{cursor:pointer;border:none;border-radius:12px;align-items:center;gap:.75rem;padding:1rem 2rem;font-size:1.05rem;font-weight:600;transition:all .2s;display:flex}.btn-guide{background-color:var(--bg-surface);color:var(--text-main);border:1px solid var(--border-color)}.btn-guide:hover{background-color:var(--bg-hover);transform:translateY(-2px)}.btn-license{color:#fff;background:linear-gradient(135deg,#f59e0b,#d97706);box-shadow:0 4px 15px rgba(245,158,11,.3)}.btn-license:hover{background:linear-gradient(135deg,#fbbf24,#d97706);transform:translateY(-2px);box-shadow:0 6px 20px rgba(245,158,11,.4)}